Blar i forfatter "Lorentzen, Elias Myrvoll"

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    • Early fulminant BK polyomavirus-associated nephropathy in two kidney transplant patients with low neutralizing antibody titers receiving allografts from the same donor 

      Lorentzen, Elias Myrvoll; Henriksen, Stian; Kaur, Amandeep; Kro, Grete Birkeland; Hammarström, Clara; Hirsch, Hans H; Midtvedt, Karsten; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed; Mastergradsoppgave; Master thesis, 2020-01-10)
      <i>Background</i> - BK Polyomavirus (BKPyV) causes premature graft failure in 1 to 15% of kidney transplant (KT) recipients. High-level BKPyV-viruria and BKPyV-DNAemia precede polyomavirus-associated nephropathy (PyVAN), and guide clinical management decisions. In most cases, BKPyV appears to come from the donor kidney, but data from biopsy-proven PyVAN cases are lacking. Here, we report the early ...

    • An investigation of BK Polyomavirus replication in tubular epithelial cells: New insights into kidney dissemination and neutralising antibodies 

      Lorentzen, Elias Myrvoll (Doctoral thesis; Doktorgradsavhandling, 2024-05-24)
      BK Polyomavirus (BKPyV) infects most humans and causes an unnoticed lifelong infection of kidney epithelial cells. In immunosuppressed kidney transplant recipients, unchecked high-level BKPyV replication causes BKPyV nephropathy, a disease leading to reduced allograft function and premature allograft loss. The aim of this thesis was to learn more about BKPyV replication and dissemination, as such ...

    • Modelling BK Polyomavirus dissemination and cytopathology using polarized human renal tubule epithelial cells 

      Lorentzen, Elias Myrvoll; Henriksen, Stian; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-28)
      Most humans have a lifelong imperceptible BK Polyomavirus (BKPyV) infection in epithelial cells lining the reno-urinary tract. In kidney transplant recipients, unrestricted high-level replication of donor-derived BKPyV in the allograft underlies polyomavirus-associated nephropathy, a condition with massive epithelial cell loss and inflammation causing premature allograft failure. There is limited ...